We investigated the linkage of EHD2 to store-operated calcium entry (SOCE) (Chung et al., 2017), a pathway that operates at caveolae (Pani and Singh, 2009; Bohórquez-Hernández et al., 2017) and is a well-established pro-metastatic signaling pathway in TNBC and other cancers (Mo and Yang, 2018; Yang et al., 2009). The gene discussed is EHD2; the disease is cancer.