Several factors could account for the discordance, including the lack of validation of antibodies in prior studies, the high EHD2 expression in normal mammary adipocytes (Figure 1B), resulting in apparent reduction in EHD2 expression in tumor tissue using western blotting (Yang et al., 2015; Shen et al., 2020; Shi et al., 2015), and the possibility that EHD2 signals in prior studies represented nuclear EHD2, which we find is associated with positive prognostic factors (Figure 3B, Supplementary file 1-Table 1). Here, EHD2 is linked to neoplasm.