A set of 14 transcripts that increased their abundance after infection with all four viruses, including PBM-HKU1, PBM-OC43, PBM-MERS, or PBM-SARS2, was upregulated in all cases, whereas 1 (STK33) was downregulated in comparison with the infection by a SARS-CoV including a nonfunctional PBM that was replaced by four glycines (Fig. 5B). The gene discussed is STK33; the disease is infection.