However, in line with an expanding number of studies showing strain to strain variation of A. fumigatus phenotypes, immune responses, and virulence in various models of infection (22), CF48 from the three parental isolates tested (CEA10, ATCC 46645, and a nonhomologous end joining deficient mutant ΔakuBKU80) elicited JNK and p38 phosphorylation to significantly different extents (Fig. S2A to C). The gene discussed is MAPK8; the disease is infection.