TGM2 and infection: Infection with 107 bacteria of the Gram-positive organism Corynebacterium diphtheriae, 107 bacteria of the Gram-negative organism P. aeruginosa, or HSV-1 at a multiplicity of infection (MOI) of 1 induced the maximum expression of innate immune response genes, including colony-stimulating factor 3 (CSF3), interleukin-1β (IL-1β), transglutaminase 2 (TGM2), and proto-oncogene tyrosine-protein kinase Src (SRC), under our experimental conditions (Fig. S1).