AGT and aneurysm: In the chronic Ang II setting, signals of SMMHC and αSMA are significantly diminished in the media layer of aortas at the aneurysm site in CCN2SMCΔ mice compared with those in both the aneurysm and nonaneurysm sites in CCN2-floxed control mice, henceforth CCN2fl/fl mice (Figure 2G and Supplemental Figure 1C).