In the CCN2fl/fl group, 46% of the mice developed aneurysms in the suprarenal region of the abdominal aortas, while 91% of the SMC-specific CCN2-KO mice, henceforth CCN2SMCΔ mice, developed aneurysms exclusively in the infrarenal segments, the identical anatomic location where human AAA occurs (Figure 2, A and C). This evidence concerns the gene CCN2 and aneurysm.