Finally, we found low frequencies of CD4+ T cells expressing IL-22 binding protein (IL-22BP) and a consistent frequency of CD4+ T cells expressing IL-4 (i.e., Th2 polarization state), but we did not see any difference between NAFLD and NASH patients (Supplemental Figure 5, A and B). Here, IL22RA2 is linked to metabolic dysfunction-associated steatohepatitis.