By random forest machine learning, we identified the most important features to discriminate between NAFLD and NASH, which include clinical parameters as well as IL-10–, IL-17A–, and TNF-α–producing CD4+ T cells and IL-17A/TNF-α–coproducing CD4+ T cells (Figure 4D). Here, IL10 is linked to metabolic dysfunction-associated steatohepatitis.