Overall, our analysis reveals the landscape of the CD4+ T cell populations in the liver of NAFLD patients, including 1 population of cytotoxic effector memory T cells, 2 distinct central memory populations, and Trm-like cells characterized by a continuum of different cell states, namely Th1, Th17, and Tr1 cells. The gene discussed is CD4; the disease is metabolic dysfunction-associated steatotic liver disease.