CD4 and metabolic dysfunction-associated steatohepatitis: We found that different populations of multicytokine-producing CD4+ T cells are significantly enriched in the liver of NASH compared with NAFLD patients, namely cells coproducing TNF-α/IFN-γ, IFN-γ/IL-17A, IFN-γ/IL-10, TNF-α/IL-17A, TNF-α/IL-10, TNF-α/IFN-γ/IL-10, and TNF-α/IFN-γ/IL-17A (Figure 4C).