Among the different multicytokine-producing CD4+ T cells, we discovered that CD4+ T cells producing mainly IL-17A, but not exclusively — i.e., CD4+ T cells with a Th17 polarization state — were significantly enriched in the liver of NASH patients with fibrosis compared with no fibrosis (Figure 5A). The gene discussed is CD4; the disease is metabolic dysfunction-associated steatohepatitis.