The published datasets also showed that the expression of TSPAN7 was decreased in the brain tissues from patients of ASD, Huntington’s disease (HD), Parkinson’s disease (PD), and Alzheimer’s disease (AD) (Fig 1C–F, *P < 0.05, **P < 0.01, n.s, not significant). This evidence concerns the gene TSPAN7 and early-onset autosomal dominant Alzheimer disease.