For example, high HAPLN1 expression in lung tumors of mesothelioma patients (Ivanova et al, 2009), liver tumors of hepatocellular carcinoma patients (Mebarki et al, 2016), and triple-negative breast cancer patients with a TME that promoted immune evasion (Kok et al, 2022) positively correlated with shorter overall survival (OS). This evidence concerns the gene HAPLN1 and hepatocellular carcinoma.