Furthermore, interactions of structural ECM proteins of the MM TME with their cognate adhesion receptors on the MM cell surface, such as fibronectin with α5β1 integrin (Hazlehurst et al, 2000) and laminin-1 with 67LR (Vande Broek et al, 2001), have been reported to induce drug resistance in MM cells. Here, FN1 is linked to Miyoshi myopathy.