2010). Higher HOMA-IR values indicate impaired insulin resistance. Our results (Table 1) showed that untreated STZ-NA-induced DM mice exhibited substantially higher HOMA-IR values in parallel with an increase in oxidative stress marker levels and reduced GLUT4 protein levels in the muscle, which indicates that insulin resistance was successfully developed in STZ-NA-induced DM mice. We also observed a negative correlation between increased lipid peroxidation and reduced GLUT4 protein levels in the muscles of mice (Figure 10). Here, SLC2A4 is linked to Insulin resistance.