Due to the importance of TGF‐β in promoting key tumorigenic events, and its critical contribution to the tumour progression, therapy resistance and metastasis, we aimed to discuss about the impact of this cytokine in regulation of immune checkpoints with a particular focus over PD‐(L)1 checkpoints, which is a hot topic of the current years in the area of cancer therapy. The gene discussed is CD274; the disease is cancer.