Thus, relation between hypoxia with increased TGF‐β signalling and EMT state of tumour is predictable, and it seems that such interrelations finally promote PD‐L1 upregulation in tumour area, as it also attested a positive correlation between HIF‐1 activity with increased PD‐L1 expression on tumour cells.73 The gene discussed is TGFB1; the disease is neoplasm.