NLRP3 and acne: Previously we reported that phenolic compounds judged to be major components of the Quercus genus have antioxidant and anti-inflammatory activity [26, 27], and based on that, the goal of this study was to elucidate the structures of phenolic compounds isolated from QA leaves and further evaluate their antioxidant and anti-inflammatory activities including inhibitory activity against acne-associated proteins (NLRP3, IL-1β, and 5α-R1) in an effort to identify potential treatments for acne.