PNPLA3 and hepatocellular carcinoma: In this patient setting, it seems that some genetic factors and in particular some single nucleotide polymorphism (SNPs) predispose to the development of HCC, for example, the rs738409 variants in patatin-like phospholipase domain-containing 3 (PNPLA3) and rs58542926 variants in transmembrane 6 superfamily member 2 (TM6SF2) (4).