In conclusion, our research indicates that the EBNA1 protein is likely related to the upregulation of some p53-inhibiting genes in the EBNA1-harboring cells at the mRNA level, and upregulation of p53-inhibiting gene collection may be a key mechanism in EBV-associated gastric adenocarcinoma (latency type I). This evidence concerns the gene TP53 and gastric adenocarcinoma.