PPFIA4 and cancer: RNA sequencing data from the nine different hypoxic-conditioned cancer cell lines (A549, BeWo, U78-MG, HCT116, Hela, MCF-7, ASPC-1, T47D, and BCPAP) were analyzed, and 23 common DEGs were identified (Fig. 1), including EGLN3, ANGPTL4, GPR146, C4orf47, KCTD11, CA9, PPFIA4, PLOD2, HK2, and TMEM. Interestingly, all of these genes were upregulated in the hypoxic-conditioned cancer cell lines.