Twelve hub proteins, including GAPDH, LRP1, ALDOA, EFEMP2, PLOD2, CA9, EGLN3, HK, PDK1, KDM3A, UBC, and P4HA1, were identified in this network based on degrees (>10), MCC, and BC (Fig. 3 and Table 3). This evidence concerns the gene PLOD2 and breast cancer.