PIK3CA and breast cancer: Adipocyte-derived IL-6 and leptin promote breast cancer metastasis by activating the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathways, thus upregulating lysyl hydroxylase (PLOD2) expression [130].