After coculture with CAFs, the expression levels of S100 calcium-binding protein A4 (S100A4), TGF-β, fibroblast growth factor (FGF)2, FGF7, matrix metalloproteinase (MMP)-2, MMP9, MMP11, platelet-derived growth factor (PDGF) A, PDGFB, vascular endothelial growth factor A (VEGFA), IL-6, IL-8, urokinase-type plasminogen activator (uPA), and tissue inhibitor matrix metalloproteinase 1 (TIMP1) in breast cancer cells are increased [109]. This evidence concerns the gene PLAU and breast cancer.