The alteration of human giant larvae homolog 1 (HUGL1) on breast cancer cell membrane can relieve the inhibition of Yes-Associated Protein (YAP), thus activating the transcription and expression of c-MYC and promoting the occurrence of Caspase-3 dependent apoptosis of adjacent cells with lower c-MYC expression, which leads to promotion of breast cancer cells with high expression of c-MYC to outcompete other cells in cell competition [183]. This evidence concerns the gene CASP3 and breast cancer.