Vitamin E, selenium, zinc, resveratrol, silymarin, probucol, and crocin can help improve insulin, vitamin E can improve insulin resistance and insulin sensitivity [110], selenium can improve insulin sensitivity [111], zinc can regulate insulin receptor, which is an insulin-like substance [112, 113], silymarin can improve insulin resistance [114], and resveratrol can increase insulin sensitivity [115] and improve insulin resistance. The gene discussed is INS; the disease is Insulin resistance.