Fufang-Zhenzhu-Tiaozhi (FTZ), with oxidative stress effect, experiments showed that the protein expression of oxidative stress factors HO-1 (hemoglobin oxygenase-1 (hypocretin-1)), NQO1 (Quinone oxidoreductase (NAD(P)H Quinone Dehydrogenase 1)) and Nrf2 was downregulated in the DKD model, and the protein expression of HO-1, NQO1, and Nrf2 in kidney tissues of the FTZ group was upregulated [65]. Here, NFE2L2 is linked to diabetic kidney disease.