ANO5 and hyperinsulinemic hypoglycemia, familial, 4: The significant hyperCKemia associated with muscle necrosis on biopsy, onset as a calf myopathy with subsequent fast progression in adulthood, and the distribution of MRI changes (adductor longus and magnus, gluteus minimus and semimembranosus, together with abnormalities on T2-STIR images and some degree of asymmetry) closely resembled LGMDR12, which is associated with anoctamin 5 (ANO5) deficiency [32].