This exploratory data-driven study provides a starting point for further research into mechanisms of impaired cognition that may be related to different neurotransmitters for each sex, into the role of ammonia waste management in the AD brain, the relationship between AD and oxidative stress initiated by NOS, the roles of long-chain FFA in memory, and the relevance of LPLs and lysophosphatidic acid metabolism in the development of AD in females. This evidence concerns the gene NOS1 and Alzheimer disease.