Consistently, the tumor growth and metastatic potentials of ID8 Cxcr1/2 CRISPRi cells with GFP/Luc were remarkably reduced in the WT mice as well as the Yap1+/− and Yap1−/− mice without any apparent change in survival and body weight (Figs. 6B-D, and Figs. S5D-G). Here, CXCR1 is linked to neoplasm.