RPS6KB1 and Alzheimer disease: As the cognitive performance of AD mouse models has a strong inverse correlation with mTOR/p70S6K signaling [12] and although inhibition of mTOR/p70S6K improves memory deficits and delays pathological progression in AD mice [67–69], mTOR/p70S6K is also required for synaptic function and memory [13, 70], moderate inhibition of mTOR/p70S6K signaling for AD treatment or prevention may be appropriate [71].