GO analysis showed that the numbers of biological process, cellular component, and molecular function of AGS against CRC were 1079, 44, and 132, respectively, and KEGG enrichment suggested that 96 signaling pathways in all would probably be involved in AGS against CRC, among which MAPK signaling pathway, lipid and atherosclerosis, proteoglycans in cancer, prostate cancer, adherens junction would probably be the major pathways. The gene discussed is JAG1; the disease is colorectal carcinoma.