SRC family kinase is a key mediator of cellular tumor-promotion genic signals linked with tumor proliferation, migration, and invasion, and SRC could be activated in CRC through various mechanisms, including the regulations of the SRC-STAT3 signaling pathway, SRC-CTNNB1, and macro-autophagy/autophagy pathways [56, 57]. Here, STAT3 is linked to colorectal carcinoma.