For instance, in breast cancer (n = 753), there is a positive correlation between CRYAB expression and Ras/MAPK (r = 0.1863, p = 2.6 × 10−7); PI3K/Akt (r = 0.1904, p = 1.4 × 10−7); epithelial–mesenchymal transition (EMT) score (r = 0.2750, p = 1.6 × 10−14); apoptosis (r = 0.1238, p = 0.0007); autophagy (r = 0.1492, p = 6.3 × 10−7); angiogenesis ( r = 0.3059, p = 6.8 × 10−25); and hypoxia based on Elvidge et al. (r = 0.5320, p = 1.2 × 10−79) and negative correlation with hormone expression (Additional file 1: Fig. S3a, 3b and 3c). This evidence concerns the gene AKT1 and breast cancer.