The first region is a ~ 75 kb fragment in size including the ZNF238 gene and responsible for corpus callosum abnormalities; the second region contains the AKT3 gene that responsible for microcephaly; the last region is a ~ 100 kb fragment that overlaps HNRNPU, FAM36A and NCRNA00201 genes and is proposed to be the candidate region for seizures [10–12]. The gene discussed is HNRNPU; the disease is microcephaly.