Participants who reported slow walking pace were older, more likely to be female, non-white, and smokers; had lower physical activity and education levels; less likely to drink and to have healthy diet scores, more likely to have CVD, hypertension, depression, and diabetes, and had higher deprivation index, BMI, CRP, APOE ε4 dosage, and lower albumin levels (all P values < 0.001). Here, APOE is linked to depressive symptom measurement.