Circulating ApoBDs affect MSCs and ameliorate osteopenia by multiple cellular factors, such as ApoBDs-derived ubiquitin ligase RNF146 and miR-328-3p, which lead to Axin1 undergoing Poly-ADP-ribosylation (PARsylation) by Tankyrases 1 and 2 (Tnks1/2) and activate the Wnt/β-catenin signal. This evidence concerns the gene TNKS and Osteopenia.