SCT and alcoholic liver cirrhosis: By immunohistochemistry in liver sections, we observed an increase in the number of (i) F4/80- and CD68-positive cells in EtOH-fed WT mice compared to CD-fed WT mice, which decreased in EtOH-fed Sct−/− mice compared to EtOH-fed WT mice; and (ii) CD68 in liver samples from patients with alcoholic cirrhosis compared to the healthy control livers (Fig. 7A–B).