It was revealed that CACNA2D3 promoted radiation-induced apoptosis by regulating intracellular calcium ion concentration; and affected the expression of several genes, correlating with the activity of multiple signaling pathways in oesophageal cancer (Fig. 5); in particular, CACNA2D3 inhibited the phosphorylation of PI3K and AKT [21]. This evidence concerns the gene AKT1 and carcinoma of esophagus.