As the PI3K/AKT signaling pathway is highly activated in NPC and is closely associated with tumor radiotherapy sensitivity, CACNA2D3 is involved in regulating PI3K, and we speculate that this may be the mechanism by which variants in the CACNA2D3 gene are associated with the occurrence of radiotherapy resistance in patients. Here, CACNA2D3 is linked to nasopharyngeal carcinoma.