To examine sex-specific associations of lipid traits potentially relevant to the aetiology of CVD, i.e. apoB, TG and Lp(a), with type 2 diabetes risk, glycemic traits and sex hormones, we conducted a Mendelian randomization (MR) study, i.e., an instrumental variable analysis with genetic instruments [25]. This evidence concerns the gene APOB and type 2 diabetes mellitus.