Because 5-LO inhibition with CJ-13610 attenuated inflammation and bone loss in lipopolysaccharide (LPS)-induced periodontal disease [26] and we previously found that short term inhibition of 5-LO resulted in reduced inflammatory mediator and RANKL synthesis during AP development [12], we sought to investigate the effects of systemic administration of MK-886 for 7 and 14 days in mature AP. The gene discussed is ALOX5; the disease is periodontal disorder.