The treatment of RA rats with HQGZWWD can up-regulate the level of anti-inflammatory cytokines IL-4 and IL-10 in serum, down-regulate the level of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α, and reduce the expression of NF-κB in synovial tissue [22]. Here, TNF is linked to rheumatoid arthritis.