Then, we performed MR analysis using these 54 SNPs, and the results of the IVW method showed a causal effect of the circulating CRP levels on the risk of IPF (ORIVW = 1.446, 95% CI 1.128–1.854, P = 0.004) (Table 1). The gene discussed is CRP; the disease is idiopathic pulmonary fibrosis.