Controlling for other potential predictors, individuals with SOT/HSCT had 57% [HR:1.57 (95% CI: 1.16, 2.13)] and PID/SID had 114% [HR: 2.14 (95% CI: 1.65, 2.77)] higher risk of cancer compared to recipients of TNF-i therapy. This evidence concerns the gene TNF and cancer.