CNR1 and fragile X syndrome: In humans, rare heterozygous genetic (missense) variants in CNR1 and DAGLA, the genes encoding the CB1 receptor and the DAGL-α enzyme, have been shown to be associated with sleep and memory disorders—alone or in combination with anxiety, and with seizures and neurodevelopmental disorders, including abnormalities of behavior and brain morphology similar to those observed in FXS patients [45].