In vitro killing of MAGE-A4+ tumor cells by CD8+ afami-cel was significantly greater compared with CD4+ afami-cel (at 72 hours: median, 79.9% (range, 33.5−97.6%; n = 37) versus median, 6.6% (range, −8.7% to 52.9%; n = 35), respectively; P = 5.8 × 10−11 (paired Wilcoxon test)). Here, CD4 is linked to neoplasm.