Serum IFNγ (Fig. 3a), interleukin 6 (IL-6) (Extended Data Fig. 7a) and granulocyte–macrophage colony-stimulating factor (GMCSF) (Extended Data Fig. 7b) levels were relatively greater in patients with Grade ≥3 CRS versus Grade ≤2 CRS and without CRS (Supplementary Table 8). The gene discussed is IFNG; the disease is congenital rubella syndrome.