Most of these genes were associated with cancers of metabolic systems (DUSP6, SGK1, BMP4, RASGRF1, GDF15) followed by breast cancer (CACNA2D3, ITGB7), cancers of the central nervous system (PRKCA), or leukemia (MECOM, JAK3). This evidence concerns the gene CACNA2D3 and breast carcinoma.