In a resting-state fMRI of unmedicated patients with major depression, increased C-reactive protein (CRP) was associated with reduced connectivity between the ventral striatum and vmPFC and that of the dorsal striatum with the vmPFC and supplementary motor area (SMA), which are associated with depression’s core symptoms of bradykinesia and psychomotor slowing, respectively [71]. Here, CRP is linked to major depressive disorder.