CNR1 and Anxiety: Both substances are pharmacologically active: THC acts a partial CB1-R agonist, whereas CBD has antagonist/inverse agonist effects at the CB1-R in addition to other anxiety-relevant actions, including effects at TRPV1, 5HT1A-R and peroxisome proliferator-activated receptor gamma (PPAR-γ) (Melas et al., 2021).