To investigate whether these splice variants were involved in the progression of colon cancer cells, the shRNAs respectively targeting against SLMAP-L (sh-SLMAP-L), SLMAP-S (sh-SLMAP-S), and CETN3-S (sh-CETN3-S), CETN3-L (sh-CETN3-L) were synthesized respectively. The gene discussed is CETN3; the disease is colonic neoplasm.