CREB1 and neoplasm: It participates invarious biological processes, such as DNA damage repair, pre-mRNA splicing,transcriptional regulation, nuclear RNA retention, in addition to being associatedwith several tumor types (Feng et al., 2020).Previous studies have demonstrated that NONO is necessary for cAMP-dependentactivation of CAMP response element-binding proteins (CREB) target genes (Amelio et al., 2007), an important pathway inseveral tumor types, including BC (Ma et al.,2019; Feng et al.,2020).