In contrast to cMET inhibitors, EZH2 inhibitor required higher IC50 concentrations (Figure 5—figure supplement 1) to diminish trimethylation of histone lysine 27 (H3K27me3; Figure 5—figure supplement 1) and colony-forming ability (Figure 5—figure supplement 1D, E) in chondrosarcoma cell lines. The gene discussed is EZH2; the disease is chondrosarcoma.