Upregulation of autophagosomes in hippocampal CA1 pyramidal neurons is related to changes in expression of autophagy-related genes (ATG3, ATG5, ATG12, ULK1 and PIK3C3/VPS34) and proteins (LC3B-II and LC3B-I) at early AD stages [63]. The gene discussed is PIK3C3; the disease is Alzheimer disease.