With the exclusion of circulating ANCA and anti-GBM effects, we hypothesize a pathogenic role for PLA2R autoimmunity in a crescent formation, but as primary membranous nephropathy with crescent is relatively rare, there are no uniform studies on the diagnosis and mechanism of the disease, and we will expand our sample size for further analysis. The gene discussed is PLA2R1; the disease is Autoimmunity.