Plasma vWF antigen (vWF: Ag), high molecular weight multimers, and propeptide levels of vWF (vWFpp) are established markers of endothelial injury [119, 120], markedly elevated during COVID-19 and may be crucial in endotheliitis and pulmonary microvascular occlusion in the pathogenesis of COVID-19 [121]. This evidence concerns the gene VWF and COVID-19.