In patients with antiphospholipid syndrome after the first thromboembolic episode, the risk of the new episode is especially high if LA is present together with high IgG aCL titers, as shown in the meta-analysis of 25 studies [66], or in triple positive patients (LA + IgG aCL + IgG antiß2GPI) [67, 68]. Here, ACLY is linked to antiphospholipid syndrome.