VWF and blood coagulation disease: Furthermore, McConnell MJ et al. revealed significant elevations of serum IL-6 as well as several biomarkers of coagulopathy and endotheliopathy, such as factor VIII, fibrinogen, d-dimer, and von Willebrand factor (vWF) in 43 COVID-19 patients with liver injury, and demonstrated the histological expression of these coagulation factors in liver sinusoidal endothelial cells (LSECs) in the biopsy specimens [45].