Treatment of ICI colitis depends on the severity, with corticosteroids often used in grade 2 or higher, with or without non-steroid immunomodulators such as blockade of TNF-α (Infliximab) or the gut-homing α4β7 integrin (Vedolizumab; Schneider et al., 2021; Tian et al., 2018). This evidence concerns the gene TNF and colitis.