Interestingly, all four genes have been shown to have roles in cancer cells: SIAH2 was shown to promote cell invasiveness in human gastric cancer cells by interacting with ETS2 and TWIST1 (92); MTDH regulates proliferation and migration of esophageal squamous cell carcinoma cells (93); the absence of HNRNPK reduces cell proliferation, migration, and invasion ability in human gastric cancer cells (94); and repression of NCOR2 and ZBTB7A increased cell migration in lung adenocarcinoma cells (95). Here, MTDH is linked to esophageal squamous cell carcinoma.