RYR2 and lung cancer: A total of five mutation genes (TP53 (Skoulidis and Heymach, 2019), KRAS (Ferrer et al., 2018), RYR2 (Yu et al., 2015), PCLO (Qiu et al., 2019), CSMD3 (Zhang et al., 2019)) linked to the pathogenesis of lung cancer were selected to make a comparison between the three clusters.