A total of five mutation genes (TP53 (Skoulidis and Heymach, 2019), KRAS (Ferrer et al., 2018), RYR2 (Yu et al., 2015), PCLO (Qiu et al., 2019), CSMD3 (Zhang et al., 2019)) linked to the pathogenesis of lung cancer were selected to make a comparison between the three clusters. This evidence concerns the gene PCLO and lung cancer.