So far, a total of 392 PLP1 mutations have been reported to be associated with SPG2, multiple sclerosis, hypomyelination of early myelinating structures (HEMS), Pelizaeus–Merzbacher disease (PMD), autism, neurodevelopmental disorders, and early‐onset neurological disease trait (EONDT),15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27 which differ in the onset, severity of symptoms and neuroimaging findings.17 This evidence concerns the gene PLP1 and multiple sclerosis.