To further validate the physiological correction between exogenous Gal-9 and endogenous Gal-9, we knocked out endogenous Gal-9 in primary B cells by nucleofection, and we found that Gal-9 knockout in B cells obstructed the colony formation and proliferation of EBV-infected B cells at the early infection stage and the outgrowth of EBV-transformed cell clones (Fig. 2E and F and Fig. S3C and D). This evidence concerns the gene LGALS9 and infection.