As we observed CCND2, SHH, and FOXM1 overexpression in response to CSC and a similar or higher level in NSCLC cancer cell lines, we, therefore, treated Beas‐2B cells with short interfering RNAs (siRNAs) for all the three genes in order to determine the effect of silencing these genes in centrosome clustering. The gene discussed is SHH; the disease is non-small cell lung carcinoma.